Carica Papaya; A Paired and Alternative Therapy of Dengue Fever

  • Shagufta Nesar Faculty of Pharmaceutical Sciences, Hamdard Medical University, Pakistan
  • Kiran Rafiq Omer Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Pakistan
  • Sarwat Rizvi Faculty of Pharmacy, Hamdard University, Pakistan
  • Aatka Ali Faculty of Pharmacy, Hamdard University, Pakistan
  • Tayyaba Mumtaz Faculty of Pharmacy, University of Karachi, Pakistan
  • Mohammad Shair Ali Usmani Jinnnah Sindh Medical College, Jinnnah Sindh Medical University, Pakistan
Keywords: Dengue, Alternative Therapy, Carica Papaya, Leaf Extract, Viral Fever

Abstract

The purpose f the study is to explore the prospective use of Carica papaya leaves extracts for Dengue fever that is a painful, debilitating mosquito-borne disease caused by dengue viruses. An estimated 390 million dengue infections occur worldwide each year, with about 96 million resulting in illness. It has been found at height in developing nations like India, Pakistan, Sri Lanka and Bangladesh. Mostly tropical areas have been reported infected. The disease is transmitted by an Aedes mosquito infected with a dengue virus; interestingly it is not transferred from person to person. Symptoms are mild to serious  including hemorrhagic fever; a rare complication characterized by high fever, damage to lymph and blood vessels, bleeding from the nose and gums, enlargement of the liver, and failure of the circulatory system and it can cause the death. All the symptoms of disease are due to low platelets count that may become very low if not managed. Consequently the research reveals that juice of the leaves of the Carica papaya plant from the family Caricaceae help to increase the platelet levels. The present review is done to enlighten the theory of the management of dengue through this alternative therapy that can be implement along with conventional treatment. The covered researches in present study would raise and support the possibility of being, the remedy and significant alternative in the prospect.

Author Biographies

Shagufta Nesar, Faculty of Pharmaceutical Sciences, Hamdard Medical University, Pakistan

Faculty of Pharmaceutical Sciences, Hamdard Medical University, Pakistan

Kiran Rafiq Omer, Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Pakistan

Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Pakistan

Sarwat Rizvi, Faculty of Pharmacy, Hamdard University, Pakistan

Faculty of Pharmacy, Hamdard University, Pakistan

Aatka Ali, Faculty of Pharmacy, Hamdard University, Pakistan

Faculty of Pharmacy, Hamdard University, Pakistan

 

Tayyaba Mumtaz, Faculty of Pharmacy, University of Karachi, Pakistan

Faculty of Pharmacy, University of Karachi, Pakistan

Mohammad Shair Ali Usmani, Jinnnah Sindh Medical College, Jinnnah Sindh Medical University, Pakistan

Jinnnah Sindh Medical College, Jinnnah Sindh Medical University, Pakistan

References

Murthy JM, Rani PU. Biological activity of certain botanical extracts as larvicides against the yellow fever mosquito, Aedes aegypti L. J Biopest. 2009;2:72–76.

Akram W, Khan HAA, Hafeez F, Bilal H, Kim YK, Lee JJ. Potential of citrus seed extracts against Dengue fever mosquito, Aedes albopic Tus (Skuse) (Culicidaea) Pak J Bot. 2010;42:3343–3348.

Maheswaran R, Satish S, Ignacimathu S. Larvicidal activity of Leucas asper (Willd) against the larvae of Culex quinquefasciatus Say. and Aedes aegypti L. Inter J Integrative Biol. 2008;2:214–217.

Health Home > Lifestyle > Heal, 13 April, 2014.

Ferreira GL. Global dengue epidemiology trends. Rev Inst Med Trop Sao Paulo. 2012; 54 (Suppl 18): S5–6.

Hettige S .Carica papaya leaf extract in Dengue fever. IMPA Journal |December 2015|Volume 09|Number 01, IMPA Journal; pg 11-14.

Subenthiran, S., Choon, T., Cheong, K., Thayan, R., Teck, M., Muniandy, P. K., Afzan, A., Noor Rain Abdullah, R. N., and Ismail, Z. Carica papaya Leaves Juice Significantly Accelerates the Rate of Increase in Platelet Count among Patients with Dengue Fever and Dengue Haemorrhagic Fever. EvidenceBased Complementary and Alternative Medicine. Volume 2013 (2013), Article ID 616737, 7 pages.

Halim, Z. S., Abdullah, R. N., Afzan, A., Abdul Rashid, A. B., Jantan, I., Ismail, Z. Acute toxicity study of Carica papaya leaf extract in Sprague Dawley rats. Journal of Medicinal Plants Research Vol. 5(xx), pp. 1867-1872, 18 May, 2011.

Lee, S. H., Tang, Y. Q., Rathkrishnan, A., Wang, S. M., Ong, K. C., Manikam, R., Payne, B. J., Jaganath, I. B., Sekaran, S. D. Effects of cocktail of four local Malaysian medicinal plants (Phyllanthus spp.) against dengue virus 2. BMC Complement Altern Med. 2013;13:192. 983

Hottz, E., Tolley, N. D., Zimmerman, G. A., Weyrich, A. S., Bozza, F. A. Platelets in dengue infection. Drug Discov Today Dis Mech. 2011;8:E33–8.

Kovendan, K., Murugan K., Naresh, K. A., Vincent, S., Hwang, J. S. Bioefficacy of larvicdial and pupicidal properties of Carica papaya (Caricaceae) leaf extract and bacterial insecticide, spinosad, against chikungunya vector, Aedes aegypti (Diptera: Culicidae) Parasitol Res. 2012;110:669–78.

Ranasinghe, P., Ranasinghe, P., Abeysekera, W. P., Premakumara, G. A., Perera, Y. S., Gurugama, P., and Gunatilake, B. S. In vitro erythrocyte membrane stabilization properties of Carica papaya L. leaf extracts. Pharmacognosy Res. 2012;4:196–202.

Sathasivam, K., Ramanathan, S., Mansor, S. M., Haris, M. R., Wernsdorfer, W. H. Thrombocyte counts in mice after the administration of papaya leaf suspension. Wien Klin Wochenschr. 2009;121 (Suppl 3):19–22.

Patil, S., Shetty, S., Bhide, R., Narayanan, S. Evaluation of platelet augmentation activity of Carica papaya leaf aqueous extract in rats. J Pharmacogn Phytochem. 2013; 1:57–60.

Sathasivam, K., Ramanathan, S., Mansor, M. S., Haris, H. M. R. M., Wernsdorfer, H. W. Thrombocyte counts in mice after the administration of papaya leaf suspension. Wiener klinische Wochenschrift. October 2009, 121:19.

Chinnappan, S., Ramachandrappa, V. S., Tamilarasu, K., Krishnan, U. M., Pillai, A. K., Rajendiran, S. Inhibition of Platelet Aggregation by the Leaf Extract of Carica papaya During Dengue Infection: An In Vitro Study. Viral Immunol. 2016 Apr;29(3):164-8. doi: 10.1089/vim.2015.0083. Epub 2016 Feb 24.

Hettige, S. Salutary effects of Carica papaya leaf extract in dengue fever patients a pilot study. Sri Lankan Fam Physician. 2008; 29:17–9.

Gowda, A. C., Kumar, N. Vijay., Kasture, P. N and Nagabhushan, K. H., 2015. A Pilot Study to Evaluate the Effectiveness of Carica Papaya Leaf Extract in Increasing the Platelet Count in Cases of Dengue with Thrombocytopenia. medind.nic.in/ice/t15/i3/icet15i3p109.

Ahmad, N., Fazal, H., Ayaz, M., Abbasi, B. H., Mohammad, I., Fazal, L. Dengue fever treatment with Carica papaya leaves extracts. Asian Pac J Trop Biomed. 2011;1:330–3.

Siddique, O., Sundus, A., and Ibrahim, M. F., 2014. Effects of papaya leaves on thrombocyte counts in dengue - a case report. Journal of Pakistan Medical Association. J Pak Med Assoc. Mar; 64(3): 364-6.

Yunita, F, Hanani E. The effect of Carica papaya L leaves extract capsule on platelet count and hematocrit level in dengue fever patient. Int J Med Aromat Plants. 2012;2:573–8.

Kumar, N. Re: Papaya leaves for speedy rise of platelet count in Dengue. Br Med J. 2010. Available from: http://www.bmj.com/rapid-response/2011/11/03/papaya-leaves-speedy-rise-platelet-countdengue.

Kala, C. P. Leaf juice of Carica papaya L: A remedy of dengue fever. Med Aromat Plants. 2012; 1:109.

Sharma, D. K., Tiwari, B., Singh, R. K., Sahu, S., Mathur, S. C., Singh, R. M., and Singh, G. N. Estimation of minerals in Carica papaya L. Leaf found in Northern India by using ICP-OES technique. Int J Sci Eng Res. 2013;4:2012–9.

Published
2018-03-05
How to Cite
Nesar, S., Omer, K., Rizvi, S., Ali, A., Mumtaz, T., & Ali Usmani, M. S. (2018). Carica Papaya; A Paired and Alternative Therapy of Dengue Fever. JOURNAL OF ADVANCES IN BIOTECHNOLOGY, 7, 975-983. https://doi.org/10.24297/jbt.v7i1.6831