Anti-herpetic activity exopolysaccharides produced by different species of lactic acid bacteria

  • Krystyna Naumenko Zabolotny Institute of microbioloy and virology of NAS of Ukraine
  • Biliavska L National Academy of Sciences of Ukraine
  • Pankivska Y Zabolotny Institute of Microbiology and Virology
  • Povnitsa O Zabolotny Institute of Microbiology and Virology
  • Vasyliuk O Zabolotny Institute of Microbiology and Virology
  • Garmasheva I Zabolotny Institute of Microbiology and Virology
  • Zagorodnya S. Zabolotny Institute of Microbiology and Virology
Keywords: exopolysaccharides, herpes simplex virus type 1, cell cycle, antiviral activity

Abstract

In the present work, it was shown that, in non-toxic concentrations, all EPSs which were isolated from lactic acid bacteria have significant anti-HSV-1 activity affecting various stages of the virus reproduction. It was demonstrated that the use of ESPs leads to the normalization of the life cycle of cells infected with the herpes simplex virus to the level of uninfected cells. It was found that EPS 26a produced by Lactobacillus sp. possesses multiple antiviral effects as it exhibits virucidal activity, blocks adsorption, penetration of the virus into cells and the release of viruses, and reduces the infectious titer of herpes simplex virus by 97-99%, indicating its considerable anti-herpetic activity.

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Author Biographies

Biliavska L, National Academy of Sciences of Ukraine

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Acad. Zabolotny str., 154, Kyiv, 03143, Ukraine

Pankivska Y, Zabolotny Institute of Microbiology and Virology

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Acad. Zabolotny str., 154, Kyiv, 03143, Ukraine

Povnitsa O, Zabolotny Institute of Microbiology and Virology

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Acad. Zabolotny str., 154, Kyiv, 03143, Ukraine

Vasyliuk O, Zabolotny Institute of Microbiology and Virology

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Acad. Zabolotny str., 154, Kyiv, 03143, Ukraine

Garmasheva I, Zabolotny Institute of Microbiology and Virology

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Acad. Zabolotny str., 154, Kyiv, 03143, Ukraine

Zagorodnya S., Zabolotny Institute of Microbiology and Virology

Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Acad. Zabolotny str., 154, Kyiv, 03143, Ukraine

 

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Published
2019-03-04
How to Cite
Naumenko, K., L, B., Y, P., O, P., O, V., I, G., & S., Z. (2019). Anti-herpetic activity exopolysaccharides produced by different species of lactic acid bacteria. JOURNAL OF ADVANCES IN BIOLOGY, 12, 2307-2315. https://doi.org/10.24297/jab.v12i0.8058
Section
Articles