This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations. The submitting author is responsible for securing any permissions needed for the reuse of copyrighted materials included in the manuscript.
While the advice and information in this journal are believed to be true and accurate on the date of its going to press, neither the authors, the editors, nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.
 Don G. Catharanthus roseus. In: Ross IA (ed). Medicinal plants of the World. Human Press, Totowa, New Jersey. 1999; pp 109-118.  WHO Traditional medicine strategy 2002-2003. WHO Publications. 2002; p 1-6.  Heijden RVD, Jacobs DI, Soneijer W, Hallard D and Verpoorte R. The Catharanthus Alkaloids.Pharmcognosy and Biotechnology. Current Medicinal Chemistry. 2004; 11(5). 607-628.  Loh KY. Know the medicinal herb. Catharanthus roseus (Vinca rosea). Malaysian Family Physician. 2008; 3 (2). 123.  James SA, Bilbiss L and Muhammad BY. The effects of Catharantus roseus aqueous leaf extract on some hematological indices as determined in rabbits. Chem. Class Journal. 2007; 4. 138-141.  Ahmad NH, Abdul Rahim R and Mat I. Catharanthus roseus Aqueous Extract is Cytotoxic to Jurkat Leukaemic T-cells but induces the Proliferation of Normal Peripheral Blood Mononuclear Cells. Tropical Life Sciences Researc. 2010; 21(2), 101–113.  Upmanyu R, Dvivedi J and Saxena Y. Hepatotoxic effect of vincristine: an experimental study on albino rats. Indian J Physiol Pharmacol; 2009; 53 (3): 265-270.  Alxeandrova R, Alxeandrova I, Velcheva M and Varadino T. Phytoproducts and cancer. Experimental Pathology and Parasitology. 2000; 4. 15-25.  Dufour DR, Lott JA, Gretch DR, Koff RS and Seeff LB. Diagnosis and monitoring of hepatic injury. Recommendations for laboratory test in screening, diagnosis and monitoring. Clin. Chem. 2000; 46. 2050-2068.  Doucete F. Sodium-potassiumadenosinetriphosphatase- dependent sodium transport in the kidney. Hormonal control. Physiol Rev. 2001; 81. 345-408.  Adekomi DA. Madagascar periwinkle (Catharanthus roseus) enhances kidney and liver functions in wistar rats. International journal of biomedical and health sciences. 2010; 6, 4.245-254.  Natarajan A, Ahmed KSZ, Sundaresan S and Kumar BS. Effect of aqueous flower extract of Catharanthus roseus on alloxan induced diabetes in male albino rats. IJPSDR. 2012; 4(2).150-153.  McKenzie M. Clinical Laboratory Hematology, 2nd ed., Prentice Hall, 2010; 411-422.  Chatterjee TK. Handbook of laboratory mice and rats .1st ed., K. Chatterjee Publisher, Calcutta, 1993; 3-8.  Daniel SP and Marshall MK. Evaluation of the liver. laboratory tests. Schiff’s diseases of the liver, 8th ed. USA, JB Lippincott publications. 1999; 205-239.  Bain PJ. Liver. In. Latimer KS, Mahaffey EA, Prasse KW (eds.). Duncan and Prasse’s Veterinary Laboratory Medicine. Clinical Pathology, 4th ed. Ames, Iowa State University Press, 2003; pp 193-214.  Alexander RH and Griffith JM. Clinical/Nutritional Biochemistry. Basic Biochemical Methods. 2nd ed., Wiley-Liss, New York. John Wiley & Sons, 1992;pp111-123.  Bancroft JD and Gamble M. Theory and Practice Histological Techniques, 5th ed., Churchill Livingstone. New York, Edinburgh and London, 2002; pp126 and 173-175.  Karthikeyan S, Abdul jaleel C and Iqbal M. Antibiogram of Catharanthus roseus extracts. Global Journal of Molecular Sciences. 2008; 3(1).1-7.  Sherlock S. Assessment of liver function Disease of liver and biliary system. Sheila Sherlock, 10th ed., London, Blackwell science ltd. 1997; 17-32.  Crawford JM. Liver and biliary tract, Pathological basis of diseases. Robins and Cotran, 7th ed. 2006; 77-938.  Pincus MR and Abraham NZ. Interpreting laboratory results. In. McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. 2006; Philadelphia, Pa. Saunders Elsevier, chap 8.  Aragon G and Younossi ZM. When and how to evaluate mildly elevated liver enzymes in apparently healthy patients. Cleveland Clin. J. Med. 2010. 77(3). 195-204.  Kevin L, Hussin AH, Zhari I and Chin JH. Sub-acute oral toxicity study of methanol leaves extract of Catharanthus roseus in rats. Journal of Acute Disease. 2012; 38-41.  Upmanyu R, Dvivedi J and Saxena Y. Hepatotoxic effect of vincristine. An experimental study on albino rats. Indian J Physiol Pharmacol. 2009; 53 (3). 265-270.  Rasineni K, Bellamkonda R, Singareddy S and Desireddy S. Antihyperglycemic activity of Catharantus roseus leaf powder in streptozotocin –induced diabetic rats. Pharmacognosy Research, 2010; 2.3:195.