JOURNAL OF ADVANCES IN CHEMISTRY http://cirworld.com/index.php/jac Interested in submitting to this journal? We recommend that you review the About the Journal page for the journal's section policies, as well as the Author Guidelines. Authors need to register with the journal prior to submitting or, if already registered, can simply log in and begin the five-step process. en-US <p>Authors retain the copyright of their manuscripts, and all Open Access articles are distributed under the terms of the&nbsp;<a href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</a>, which permits unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.</p> <p>&nbsp;</p> editor@cirworld.com (Editorial Office) jac@rajpub.com (Gurpreet kaur) Thu, 31 Jan 2019 00:00:00 +0000 OJS 3.1.2.1 http://blogs.law.harvard.edu/tech/rss 60 Synthesis, Spectroscopic Characterization And Antimicrobial Evaluation of Novel Nitrogen Containing Metal Complexes http://cirworld.com/index.php/jac/article/view/8030 <p>Four novel Mn(II), Co(II), Cu(II) complexes with nitrogen containing ligand (L) i.e. N,N-((Z)-ethane-1,2-diylidine)bis(2-amino benzo hydrazide) have been synthesized and structurally characterized by elemental analysis, spectral, thermal (TG/DTG), molar conductance and magnetic susceptibility measurements. From the spectroscopic and magnetic studies it has been concluded that all complexes have a six coordinated octahedral geometry. The Schiff base and their metal complexes have also been screened for their antibacterial and antifungal activities by using a modified Kirby-Bauer disc diffusion method.</p> Hanaa A. El-Boraey, Aballah El-domiaty Copyright (c) 2019 JOURNAL OF ADVANCES IN CHEMISTRY https://creativecommons.org/licenses/by/4.0 http://cirworld.com/index.php/jac/article/view/8030 Thu, 31 Jan 2019 04:12:25 +0000 Structural And Vibrational Studies on Isomers of Antiviral Ribavirin Drug in Gas and Aqueous Environmental by Using The SQM Approach http://cirworld.com/index.php/jac/article/view/8099 <p>Five stable isomers of antiviral ribavirin agent were theoretically determined in gas and aqueous solution by using the hybrid B3LYP/6-31G* method. Here, the solvent effects were studied with the self consistent reaction field (SCRF) methodology employing the polarized continuum (PCM) and the universal solvation model (SM). Structural, electronic and topological properties were reported for all isomers while the vibrational analyses were performed only for those two polymorphic structures experimentally observed in the solid phase by X-ray diffraction. Calculations have evidenced that C2 correspond to the polymorphic V1 structure while C5 to the polymorphic V2 structure. The high dipole moment values predicted for C2 and C5 in both media could probably explain their presences in the solid. Experimental available IR and Raman spectra of ribavirin in the solid state and normal internal coordinates were employed together with the scaled quantum mechanical force field (SQMFF) approach to perform the complete vibrational assignments in both media. Here, the 81 vibration modes expected for C2 and C5 in both media were completely assigned. The frontier orbitals studies reveal that C5 is the less reactive in both media. Here, the gap value observed for C5 is in agreement with the value recently reported for ribavirin by using B3LYP/6-311++G** calculations.</p> María Florencia Ladetto, María Jimena Márquez, Davide Romani, Silvia Antonia Brandán Copyright (c) 2019 JOURNAL OF ADVANCES IN CHEMISTRY https://creativecommons.org/licenses/by/4.0 http://cirworld.com/index.php/jac/article/view/8099 Thu, 31 Jan 2019 04:14:55 +0000 Oxidative Study of Benzaldehyde by Isoqauinolinium Bromo Chromate http://cirworld.com/index.php/jac/article/view/8248 <p>The kinetics analysis of the oxidative reaction between benzaldehyde and oxidant is quinolinium Bromo chromate was reported in aqueous 40% acetic acid medium at 313 K. The rate of reaction varies first-power of [IQBC] and [H<sub>2</sub>SO<sub>4</sub>], whereas fractional-order kinetics was observed for benzaldehyde. The rate constant gradually increases with decrease in dielectric constant of the medium. The neutral salt does not alter the rate. The metal cations (Cu<sup>++</sup>) slightly accelerate the rate of oxidation when added to reaction mixture. The study rules out the participation of keto form of substrate in complex formation. Benzoic acid was identified as the end-product in stoichiometrically 1:1 based mechanism. The rate law was derived in accordance with the kinetic results.</p> Arun Kumar Dwivedi, K. N. Sharma, Arvind Prasad Dwivedi Copyright (c) 2019 Arun Kumar Dwivedi, K. N. Sharma, Arvind Prasad Dwivedi https://creativecommons.org/licenses/by/4.0 http://cirworld.com/index.php/jac/article/view/8248 Tue, 30 Apr 2019 06:57:35 +0000 Synthesis, Spectral Characterization, Thermal and In vitro Antimicrobial Studies for Novel Co(II) and Ni(II) Complexes of (N,N'-(1,2-Phenylene)Bis(2-Aminobenzamide) http://cirworld.com/index.php/jac/article/view/8264 <p>Novel metal complexes of Co(II) and Ni(II) have been&nbsp; prepared from reaction of their different salts with previously prepared ligand <strong>(L)</strong> namely (N,N'-(1,2-phenylene)bis(2-aminobenzamide). Synthesis ligand and its metal (II) complexes (<strong>1-5</strong>) were reported and characterized with the help of analytical and physiochemical analysis as elemental, IR spectra, thermal (TG/DTG), UV-Vis, magnetic susceptibility and molar conductance in DMF, On the view of the previous data and measurements, the structure and composition species behave as mononuclear and octahedral geometry has been proposed for all the complexes except for complex<strong> (1)</strong> adopted tetrahedral structure. Furthermore, the in vitro antibacterial Staphylococcus aureus (ATCC 25923) as Gram-positive strain, Escherichia coli (ATCC 25922) as Gram-negative strain and antifungal Candida albicans (ATCC 10231) have been studied for all samples using disc diffusion method against Ampicillin and Fluconazole as positive controls, respectively. The results show that complexation facilitates the activity of most studied metal complexes than the free ligand.</p> Hanaa A. El-Boraey, Azza A. Serag El-Din, Ahmed A. Sakr Copyright (c) 2019 Hanaa A. El-Boraey, Azza A. Serag El-Din, Ahmed A. Sakr https://creativecommons.org/licenses/by/4.0 http://cirworld.com/index.php/jac/article/view/8264 Tue, 30 Apr 2019 07:02:05 +0000 Levels of Toxic Metals in Skin Lightening Agents Marketed in Nigeria http://cirworld.com/index.php/jac/article/view/8317 <p>Background: Bleaching agents produced by registered companies in developed countries have regulated concentrations. But various local skin lightening agents produced in Africa, especially Nigeria have no identified active agent. This study determined the levels of potentially toxic heavy metals constituents of bleaching agents commonly used by Nigerians. Methods: Twelve different types of skin lightening creams (Extra white, Make me white, Extract, Perfect white, UV lightening, Pure skin, Body treat, Dodo up, Bronze tone, White express, Peau Claire and Otentika) available Nigerian markets were randomly collected based on their usage and availability. Three non- lightening creams served as the controls for this study. Levels of mercury, lead, cadmium, chromium and arsenic were determined in both lightening and non- lightening creams (controls) using atomic absorption spectrophotometer (AAS). Results: All lightening creams 12/12 (100%) contained significantly (p&amp;lt;0.05) higher levels of mercury compared with the control. 11/12 (91.7%) of the lightening creams contained significantly (p&amp;gt;0.05) higher levels of lead compared with the control. Levels of arsenic were significantly (p&amp;lt;0.05) higher in 11/12 (91.7%) of the lightening creams compared with control. Levels of cadmium increase significantly (p&amp;lt;0.05) in 4/12 (22.92%) of the lightening creams compared with the control. 4/12 (22.92%) of the lightening creams contained significantly (p&amp;lt;0.05) higher levels of chromium compared with control.</p> Moses Olayemi Akiibinu, Olutola Bob Soile, Lilian Esther Akinade, Susan Olufunmilayo Akiibinu Copyright (c) 2019 Moses Olayemi Akiibinu, Olutola Bob Soile, Lilian Esther Akinade, Susan Olufunmilayo Akiibinu https://creativecommons.org/licenses/by/4.0 http://cirworld.com/index.php/jac/article/view/8317 Mon, 01 Jul 2019 06:28:10 +0000 Chemical Speciation and Mobility of Heavy Metals in Soils Around Nasara Sack and Packaging Company Akwanga, Nigeria http://cirworld.com/index.php/jac/article/view/8434 <p>This study quantified and assessed the mobility of iron, nickel, cobalt and lead in soils around a sack and packaging company using indices such as mobility factor and risk assessment code. The results evaluating the mobility factor of heavy metals in soils around the sack and packaging company reveal that all the metals determined exceed the minimum limit of 10% mobility factor and are mobile with the mobility factor being in the order of: Ni &gt; Pb &gt; Co &gt; Fe in the test soil. The risk assessment of heavy metals in the area based on risk assessment code ranged from low risk to medium risk (1-30%) where the risk level of the heavy metals is in the order:&nbsp; Co &gt; Ni &gt; Pb &gt; Fe in the test soil.</p> Emmanuel Amuntse Yerima, B.N. Hikon, C.V. Ogbodo, H. Ataitiya, J.D. Ani Copyright (c) 2019 Emmanuel Amuntse Yerima, B.N. Hikon, C.V. Ogbodo, H. Ataitiya, J.D. Ani http://creativecommons.org/licenses/by/4.0 http://cirworld.com/index.php/jac/article/view/8434 Sat, 05 Oct 2019 09:35:34 +0000 The Clitocybins and 2-Substituted-Isoindolin-1-Ones: Synthesis and in Vitro Antimycobacterial Activities http://cirworld.com/index.php/jac/article/view/8476 <p>Despite strong indications of antimycobacterial activities for clitocybins reported since 1945, no reports linking chemical structure and activity have been reported in the literature since then. In this study, we synthesized some clitocybin derivatives (also called 2-substituted-isoindolinones), and tested their activities and carried out some chemical derivations. Isoindolinones were prepared from methyl 2-formyl-3,5-dimethoxybenzoate and various primary aromatic amines. Compounds were evaluated for <em>in vitro</em> activity against <em>Mycobacterium tuberculosis </em>H<sub>37</sub>Rv, as well as for cytotoxicity (CC<sub>50</sub>) on the Vero cell line. 4,6-dihydroxy-2-(4-hydroxyphenyl)isoindolin-1-one, <strong>7</strong>, and 4-hydroxy-2-(4-hydroxyphenyl)-6-methoxy-isoindol-1-one, <strong>5</strong>, exhibited the highest antimycobacterial activities (minimum inhibitory concentration = 19.45 µM and 18.45 µM, respectively) and were non-toxic (CC<sub>50</sub> = 30 µM and 29 µM, respectively).</p> Amani Mejai, Nambinina V. Rakotoarivelo , Ennaji Najahi , Pierre Perio , Etienne Hollande, Maria Rosalia Pasca, Rym Abidi, Françoise Nepveu Copyright (c) 2019 amani mejai http://creativecommons.org/licenses/by/4.0 http://cirworld.com/index.php/jac/article/view/8476 Mon, 28 Oct 2019 00:00:00 +0000 Synthesis and DFT Study of Newly Schiff Base and Fused Heterocyclic Compounds as Antibacterial Agent http://cirworld.com/index.php/jac/article/view/8499 <p>Treatment of 2,3-di-(4-chlorophenyl) oxirane-2,3-dicarbonitriles(1) with nitrogen nucleophiles, e.g. N2H4, NH2OH afforded pyrazole 2, 1.2oxazole 3 derivatives respectively The 3-amino pyrazole-4-one derivatives 2 can be used as a key starting materials to synthesize some important Schiff base 4 and fused heterocyclic compounds e.g. Imidazolo-[4,5-c]pyrazole 5, Pyrazolo[3,4-e]1,2,4-triazine 6, pyrazol[1,2-a] 1,3,5-triazine 7, 8 and 9. The electromeric effect of the halogen atom in the aryl moieties can be controlled upon the rate of reaction and the yield of the product. The structures of synthesized new compounds were characterized by spectral data and screened for their antimicrobial activities against various bacteria and fungi strains. The heterocyclic compounds 7, 8 and 9 that contained bridgehead nitrogen gave an excellent result.&nbsp;</p> Sameh Rizk, Ismail M. Awheda, Fathi A. Smida Copyright (c) 2019 Sameh Rizk, Ismail M. Awheda, Fathi A. Smida http://creativecommons.org/licenses/by/4.0 http://cirworld.com/index.php/jac/article/view/8499 Thu, 07 Nov 2019 06:06:16 +0000