Proton-Mr-Spectroscopy of the Breast: is it A Reliable Imaging Modality for Characterizing the Bi-Rads 3 And 4 Lesions Before the Biopsy?

  • Hasan Ayd?n D??kap? Y?ld?r?m Beyaz?t Research Hospital
  • Emine Öztürk D??kap? Y?ld?r?m Beyaz?t Research Hospital, Radiology Department
  • Volkan K?z?lgöz
  • Hakan Güzel D??kap? Y?ld?r?m Beyaz?t Research Hospital
  • Baki Hekimo?lu D??kap? Y?ld?r?m Beyaz?t Research Hospital
Keywords: MR Spectroscopy, Breast, Contrast Agents, Biopsy

Abstract

Aim; Our aim is to evaluate the diagnostic performance of pre and post contrast proton MR spectroscopy (H-MRS) in patients with breast imaging-reporting data system (BI-RADS) 3 and 4 lesions. Materials and Methods; After institutional review board approval and informed consent taken from all the patients; breast MR imaging and unenhanced-enhanced spectroscopy was performed in 55 patients with BI-RADS 3 and 4 lesions. We had 4 DCIS, 5 malignant tumours, 1 borderline phylloides tumour, 3 mastititis and 42 benign masses in both groups. Diagnostic interpretation was based on the BI-RADS category depending upon the Ultrasonographic-Mammographic and MRI findings. Statistical analysis of BI-RADS 3 and 4 masses were performed by Fischer’s exact test and Pearson chi square test. Results; For the evaluation of BI-RADS 3 mass lesions, pre and post-contrast spectroscopy had about 100% sensitivity and specificity. According to the BI-RADS 4 lesions; H-MRS before and after contrast admistration, presented 81-73 % sensitivity with 100 % specificity for both acquisitons. Pre and post-contrast H-MRS, had 91-85% sensitivity and 56-44% specificity for all BIRADS-3 and 4 lesions of 55 patients. Pre-contrast MR-Spectroscopy had significant statistical differences with regard to histopathology for all BI-RADS 3 and 4 lesions (p<0.05), however post-contrast spectroscopy did not have any statistical differences from the biopsy (p>0.05). Conclusion; H-MRS, especially the one performed before the contrast application, was useful for characterizing the BI-RADS 3 and 4 breast lesions, further improve the sensitivity and specificity of breast MR imaging and influence patient treatment options.

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Author Biographies

Hasan Ayd?n, D??kap? Y?ld?r?m Beyaz?t Research Hospital

D??kap? Y?ld?r?m Beyaz?t Research Hospital, Radiology Department

Volkan K?z?lgöz

D??kap? Y?ld?r?m Beyaz?t Research Hospital, Radiology Department

Hakan Güzel, D??kap? Y?ld?r?m Beyaz?t Research Hospital

D??kap? Y?ld?r?m Beyaz?t Research Hospital, General Surgery Department. ANKARA

Baki Hekimo?lu, D??kap? Y?ld?r?m Beyaz?t Research Hospital

D??kap? Y?ld?r?m Beyaz?t Research Hospital, Radiology Department1. ANKARA

Published
2019-09-12
How to Cite
Ayd?n, H., Öztürk, E., K?z?lgöz, V., Güzel, H., & Hekimo?lu, B. (2019). Proton-Mr-Spectroscopy of the Breast: is it A Reliable Imaging Modality for Characterizing the Bi-Rads 3 And 4 Lesions Before the Biopsy?. JOURNAL OF ADVANCES IN BIOLOGY, 3(1), 152-164. https://doi.org/10.24297/jab.v3i1.8441
Section
Articles