Antidiabetic and Immunomodulatory Effects of Oleuropein and Vitamin C in Diabetic Male Rats

  • Nema Abdelhameed Mohamed Alexandria University, Egypt
  • Heba Mohamed Abdou Alexandria University, Egypt
  • Marium Mohamed Marzouk Omar El-Mokhtar University, Libya
Keywords: Oleuropein, Vitamin C, Diabetes, Oxidative Stress, Immunity, Male Rats


The present work was designed to study the antidiabetic and immunomodulatory effects of olive leaf polyphenol (Oleuropein) and vitamin C in diabetic male rats. Diabetes was induced by a single i.p. dose of STZ (40 mg/kg b.w.). Pure oleuropein compound (5 mg/kg b.w.) and vit. C (150 mg/kg b.w.) were orally administered once per a day for 15 days after diabetes induction. Oleuropein and vitamin C showed a significant role in attenuating the blood glucose, insulin, pancreatic amylase, and hexokinase alterations and caused an elevation of antioxidant enzymes in diabetic rats. Oleuropein and vitamin C showed a hematopoetic action as documented by the increase in RBC, Hb, Hct, PLt, decrease in WBC and improved RBC structure. Oleuropein and vitamin C significantly attenuated the oxidative status of diabetic rats. Oleuropein and vitamin C improved the different changes in some cytokines and interlukines and decreases the gene expression of TNF-ALFA1.png, COX2, and caspase3 involved in apoptosis and inflammation. The immunohistochemical sections of pancreas in the diabetic rats treated with oleuropein and vitamin C showed a high intensity of insulin in BETA1.png-cells. Oleuropein as a natural active compound has antioxidant activity more or less like vitamin C to attenuate the effect of STZ-induced diabetes.


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Author Biographies

Nema Abdelhameed Mohamed, Alexandria University, Egypt

Department of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypt

Heba Mohamed Abdou, Alexandria University, Egypt

Department of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypt

Marium Mohamed Marzouk, Omar El-Mokhtar University, Libya

Department of Zoology, Faculty of Science, Omar El-Mokhtar University, Libya


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How to Cite
Mohamed, N. A., Abdou, H. M., & Marzouk, M. M. (2018). Antidiabetic and Immunomodulatory Effects of Oleuropein and Vitamin C in Diabetic Male Rats. JOURNAL OF ADVANCES IN BIOLOGY, 11, 2250-2268.

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